Author: Stepanov, S.A.
Paper Title Page
Beamline and Experiment Automations for the General Medical Sciences and Cancer Institutes Structural Biology Facility at the Advanced Photon Source (GM/CA@APS)  
  • S.A. Stepanov, R. Fischetti, M. Hilgart, O. Makarov, Q. Xu
    ANL, Argonne, Illinois, USA
  • J.L. Smith
    University of Michigan, Ann Arbor, USA
  Funding: GM/CA@APS has been funded in whole or in part with Federal funds from the National Cancer Institute (ACB-12002) and the National Institute of General Medical Sciences (AGM-12006).
Beamlines for macromolecular crystallography (MX) are among the most automated beamlines at synchrotron radiation facilities around the globe. GM/CA@APS operates three EPICS-controlled MX beamlines. All aspects of controls including data acquisition software, computing, networking, data storage and remote access are managed locally, which enables fast development and efficient integration of all parts of the process. The core of the GM/CA control system is the open-source JBluIce* distributed data acquisition software, which integrates automated sample screening with robotic sample mounters, automated searches for small crystals, multiple modes of data collection, and automated strategy and data processing calculations. This presentation gives an overview of JBluIce and reports recent developments to support up to 100 fps shutterless data collection with fast Dectris Eiger and Pilatus detectors. The integration involved new approaches to detector-goniometer synchronization and data visualization, redesign of the computing and storage environment, and implementation of automated distributed data processing on clusters.
*S.Stepanov et al. JBluIce-EPICS control system for macromolecular crystallography, Acta Cryst., D 67, 176-188 (2011)
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